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The 2019 APN Symposium
First Asian Pharmacometrics Network (APN) Symposium, November 2019
Bangkok Narai Hotel, Thailand

< 19th November >

Time Topic Speaker
08:15 - 08:45 am Registration -
08:45 - 09:00 am Opening Remark Suvatna Chulavatnatol, Mahidol University, Thailand
09:00 - 10:00 am Plenary Lecture 1:
Asian Pharmacometrics Network: Historical background and objectives		 Kyungsoo Park, Yonsei University, Korea
10:00 - 10:30 am Refreshment Break 1 & Poster
10:30 - 11:00 am Population PK/PD for antimalarial treatment
 Joel Tarning, Mahidol University, Thailand
11:00 - 11:30 am Pharmacometrics in the Development of Ixekizumab Laiyi Chua, Lilly, Singapore
11:30 - 12:00 am Pharmacokinetic/Pharmacodynamic-Drug Development Ariya Khumvichai, Medica Innova Co., Ltd, Thailand
12:00 - 13:00 pm Lunch & Poster
13:00 - 13:30 pm Physiologically based pharmacokinetic model application Manupat Lohitnavy, Naresuan University, Thailand
13:30 - 14:00 pm Modeling and Simulation Technique for Clinical Development of New Drugs Takahiko Tanigawa, Bayer, Japan
14:00 - 14:30 pm Bayesian Dose-Finding Phase I Trial Design Incorporating Pharmacokinetic Assessment in the Field of Oncology Kanji Komatsu, Astellas, Japan
14:30 - 15:00 pm Refreshment Break 2 & Poster
15:00 - 15:30 pm Pharmacometrics and Modeling for Biologics Wararat Limothai, Government Pharmaceutical Organization (GPO), Thailand
15:30 - 16:00 pm Population Pharmacokinetics Followed by Virtual Bioequivalence Trials Uthpali Mannapperuma, University of Colombo, Sri Lanka
16:00 - 16:30 pm Warfarin population pharmacokinetics study in patients with renal impairment Yu-Shen Yang, National Taiwan University, Taiwan


< 20th November >

Time Topic Speaker
08:30 - 09:00 am Registration -
09:00 - 10:00 am Plenary Lecture 2:Physiologically Based Pharmacokinetic (PBPK)
Modeling-An Important Tool in the Drug Development Toolkit		 Vikram Arya, FDA, USA.
10:00 - 10:30 am Refreshment Break 1 & Poster
10:30 -11:00 am Clinical pharmacometrics in real world data Dongwoo Chae, Yonsei University, Korea
11:00 - 11:30 am Development of Single and Repeated Time-to-Event Model using
Parametric Approach		 Sabariah Noor Harun, Universiti Sains Malaysia, Malaysia
11:30 - 12:00 pm Mechanistic PKPD Modelling of Primaquine Palang Chotsiri, Mahidol University, Thailand
12:00 - 13:00 pm Lunch & Poster
13:00 - 14:00 pm Plenary Lecture 3:Prioritizing Drug Candidates in Precision Oncology for Rare Cancer:
A Case Study in Thai Liver Fluke-Associated Cholangiocarcinoma		 Somponnat Sampattavanich, Mahidol University, Thailand
14:00 - 14:30 pm Voriconazole Population Pharmacokinetic Study Shu-Wen (Wendy) Lin, National Taiwan University, Taiwan
14:30 - 15:00 pm Refreshment Break 2 & Poster
15:00 - 15:00 pm Adequacy of Isoniazid and Rifampicin in Anti-Tuberculosis Treatment in Children; A Pharmacometric Approach Blessed Winston Aruldhas,
Christian Medical College, India
15:30 - 16:00 pm Applications of PBPK Modeling in Pediatric Drug Development Rama Sivasubramanian,
Novartis Healthcare Pvt. Ltd., India
16:00 - 16:30 pm Pharmacometrics and Pharmacokinetics in Nepal Bimal Kunwar,
Nobel College of Health Science, Nepal
16:30 - 17:00 pm Closing ceremony Kyungsoo Park,
Yonsei University, Korea


The 2019 APN Satellite Workshop
The First Asian Pharmacometric Network (APN) Symposium (Workshop)
On 18th November 2019 Computer Laboratory Room, 7th Floor, Ratcharat Building, Faculty of Pharmacy, Mahidol University
Time Topic Speaker
08:15 - 08:45 Registration -
08:45 - 09:00 Opening Remark Assoc. Prof. Dr. Suvatna Chulavatnatol
Dean Faculty of Pharmacy, Mahidol University, Thailand
09:00 - 09:40 Introduction to QSP Mr. Hyeonsoo PARK
Department of Pharmacology, Yonsei University College of Medicine, South Korea
09:40 - 10:30 Introduction to MALTAB/Simbiology Dr. Wooyul LEE, Department of Pharmacology, Yonsei University College of Medicine, South Korea
10:30 - 10:45 Coffee Break 1
10:45 - 11:25 Pharmacometrician’s gateway to QSP: TMDD model Prof. Dr. Dongwoo Chae, Department of Pharmacology, Yonsei University College of Medicine, South Korea
11:25 - 12:15 Introduction to QSP experiments Assist. Prof. Dr. Jungho LEE, Department of Pharmacology, Eulji University, South Korea
12:15 - 13:15 Lunch
13:15 -14:05 Cell cycle models: Goldbeter and Novak-Tyson models Prof. Dr. Dongwoo Chae, Department of Pharmacology, Yonsei University College of Medicine, South Korea
14:05 - 14:45 Modeling the RTK-MAPK pathway Prof. Dr. Dongwoo Chae, Department of Pharmacology, Yonsei University College of Medicine, South Korea
14:45 - 15:00 Coffee Break 2
15:00 - 17:00 Physiologically Based Pharmacokinetic (PBPK) workshop 1. Assoc. Prof. Dr. Manupat Lohitnavy, Naresuan University, Phitsanulok, Thailand
2. Ms. Kimheang Ya, Naresuan University, Phitsanulok, Thailand
3. Assoc. Prof. Dr. Korbtham Sathirakul, Mahidol University, Bangkok, Thailand
4. Asst. Prof. Dr. Wichit Nosoongnoen Mahidol University, Bangkok, Thailand
5. Dr. Pattarawit Rukthong, Srinakharinwirot University, Nakhon Nayok, Thailand
6. Dr. Uthpali Mannapperuma, University of Colombo, Colombo, Sri Lanka
17:00 - 17:15 Closing speech 1. Prof. Dr. Dongwoo Chae, Department of Pharmacology, Yonsei University College of Medicine, South Korea
2. Assoc. Prof. Dr. Manupat Lohitnavy, Naresuan University, Phitsanulok, Thailand
3. Assoc. Prof. Dr. Korbtham Sathirakul, Mahidol University, Bangkok, Thailand


The 2020 APN Symposium
2020 Asian Pharmacometrics Network (APN) Symposium
18-19th November (Virtual)


< 18th November >

Time* Topic Speaker
07:00 - 07:15 Registration  
07:15 - 07:30 Opening Remark Surulivelrajan Mallayasamy
07:30 - 08:20 Plenary Lecture 1 Chair: Surulivelrajan Mallayasamy
  Using pharmacometrics to explore
pharmacokinetic and pharmacodynamic
relationship in a pediatric setting		 Richard Brundage, University
of Minnesota, USA
08:20 - 08:30 Break
08:30 - 09:45 Academic Research 1
 Chairs: Lai-San Tham, Korbtham Sathirakul
  Physiologically-Based Pharmacokinetic Modelling
of Complex Drug-Drug-Disease Interactions: A
Case Study of Rivaroxaban		 Eric Chun Yong Chan,
National University of
Singapore
  Modeling adherence using
pharmcometric approaches		 Surulivelrajan Mallayasamy,
Manipal Academy of Higher
Education, India
  Population pharmacokinetic modeling to optimize
dosage regimens of antiretroviral (ARV) drugs in
Thai HIV-infected patients		 Baralee Punyawudho,
Chiang Mai University,
Thailand
09:45 - 10:10 Break
10:10 - 11:50 Clinical Research
 Chairs: Kyungsoo Park, Surulivelrajan Mallayasamy
  Dynamic predictive model for postoperative
nausea and vomiting for intravenous fentanyl
patient-controlled analgesia		 Dongwoo Chae, Yonsei
University, Korea
  Application of Pharmacometrics in Clinics Vijay Ivaturi, University of
Maryland, USA
  Utility of population pharmacokinetic model developed
from phase I study data for the further drug development		 Jaeseong Oh, Seoul National University, Korea
  Use of pharmacometrics approaches to interpret therapeutic drug
monitoring data on lithium in SriLankan patients		 Uthpali Mannapperuma, University of Colombo, Sri Lanka
11:50 - 12:30 Break
12:30 - 13:20 Plenary Lecture 2 Chair: Atsunori Kaibara
  Over Twenty Years Contribution in Educating Pharmacometrics for Japan Industry Takahiko Tanigawa, Bayer, Japan
13:20 - 13:45 Break
13:45 - 14:45 Student Session 1 Chairs: Yoke-Lin Lo
Yunn - Fang Ho
A pharmacometric time-to-event modeling for
death among Asian patients with symptomatic COVID-19		 Orwa Albitar, Universiti Sains,Malaysia
Prediction of concentration of 5-fluorouracil (5-FU) in plasma and bone
marrow by a physiologically based pharmacokinetic model after IV bolus and
continuous infusion regimens		 Chih-Jia Chao, National Taiwan University, Taiwan
Association of cigarette smoking with plasma concentration
of Efavirenz among HIV positive patients		 Chow Ngah Kuan, Universiti Sains, Malaysia
Application of PBPK model for Caffine in
clinically non-responsive neonates in the
treatment of Apnoea of prematurity 		Sahiti Thotakura, Manipal Academy of Higher Education, India
14:45-14:50 Closure of Day 1 Surulivelrajan Mallayasamy


< 19th November >

Time Topic Speaker
07:30 - 08:20 Plenary Lecture 3 Chair: Kyungsoo Park
  Predictive Health Analytics: Next big Thing Joga Gobburu, University of
Maryland, USA.
08:20 - 08:30 Break
08:20 - 08:30 Academic Research 2 Chairs: Lai-San Tham, Korbtham Sathirakul
  Population Pharmacokinetics of Levofloxacin After
Oral Administration in Healthy Indonesian Volunteers		 Akhmad Kharis Nugroho,
Universitas Gadjah Mada
Yogyakarta, Indonesia
  Repurposing Drugs for COVID-19: An approach for
treatment in the Pandemic		 Sitaram Khadka, Shree
Birendra Hospital, Nepal
  Application of population pharmacokinetic
approach in oncology		 Vikram Gota, ACTREC, India
  PK/PD simulation-based evaluation of recommended penicillin G dosage regimen
for Streptococcus spp. infective endocarditis patients		 Chotirat Nakaranurack, Chulalongkorn University, Thailand
10:10 - 10:35 Break
10:35 - 12:15 Industry/New innovations Chairs: Rama Sivasubramanian, Atsunori Kaibara
  Accelerated quantitative pharmacology analysis
with Pharmaceutical Modeling and Simulation(PUMAS)		 Vijay Ivaturi, University of Maryland, USA
  Current and Future Perspective of Model Informed Drug Development in Japan So Miyoshi, Pfizer, Japan
  Nanomedicines: PBB modelling techniques and IVIVIC Matthias Gerhard Wacker, National University of Singapore
  Application of Pharmacometrics in Drug-Drug interaction
studies and dosage prediction		 Ramachandra Sanghana, Novartis, India
12:15 - 13:00 Break
13:00 - 14:00 Student Session 2 Chairs: Surulivelrajan Mallayasamy, Korbtham Sathirakul
  Dose optimzation of Aminophylline in preterm neonates
(32 weeks of Gestational Age) based on population pharmacokinetic modeling approach		 Shivakumar, Manipal Academy of Higher Education, India
  Preliminary results: Influence of genetic and non-genetic factors
on donepezil concentrations in Thai patients with Alzheimer's disease
using population pharmacokinetic modelling approach		 Thitipon Yaowaluk, Mahidol University, Thailand
  Population pharmacokinetics of Levitiracetam in Indian epileptic patients Jeffrey Raj, KEM Hospital, India
  Impact of Albumin and Omeprazole on Steady-State Population Pharmacokinetics
of Voriconazole and Development of a Voriconazole Dosing Optimization Model
in Thai Patients with Hematologic Diseases		 Buddharat Khan-asa, Mahidol Unviersity, Thailand
14:00 - 14:15 Closing Remark Kyungsoo Park
* Indian Standard Time

The 2020 APN Satellite Workshop
PUMAS Pharmacometrics Workshop using Julia Hub
20th November (Virtual)
Lead instructor: Dr. Vijay Ivaturi, University of Maryland School of Pharmacy, MD, USA
Instructors: Dr. Vijay Ivaturi & Team
Time* Topic
08:00 – 08:15 Introductions and agenda
08:15 – 09:00 Introduction to Julia and Pumas
09:00 – 10:00 Model based simulations - Demo and Work-along
10:00 – 10:15 Break
10:15 – 11:15 Simulations – hands-on
11:15 – 12:15 Non-compartmental analysis
12:15 – 12:30 Break
12:30 – 13:30 Non-linear mixed effects model fitting
13:30 – 14:00 Wrap-up
* Indian Standard Time

The 2021 APN Workshop
Basic Pharmacometrics Workshop using Monolix
Thursday, 3 June 2021 (Virtual)
Dr. Akhmad Kharis Nugroho, Universitas Gadjah Mada, Indonesia
Dr. Géraldine Ayral, Lixoft Inc., France
Time(Jakarta time, GMT +7) Agenda
09:00 – 09:15 Opening ceremony
Prof. Dr. apt. Agung Endro Nugroho, M.Si.
Dean Faculty of Pharmacy Universitas Gadjah Mada
09:15 – 10:15 Keynote Speech: Pharmacometrics: Whether it has
arrived to deliver for all the stakeholders?
M.Surulivel Rajan M.Pharm, PhD
Manipal College of Pharmaceutical Sciences, Manipal, India
10:15 – 12.:00 Workshop part A: Data preparation and Basic Monolix operation
Prof. Dr. apt. Akhmad Kharis Nugroho, M.Si.
Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
12:00 – 13:00 Break
13:00 – 15:00 Part B: Monolix Suite for Efficient PK/PD Modelling
Dr. Géraldine Ayral
VP Application, Lixoft Inc., Francebr>
15:.00 – 15:15 Assignment announcement and closing
The 2021 APN Symposium
The 2021 APN Symposiurn
25-26th November(Virtual)

Moderators:

Yen-Ming Huang, Assistant Professor, NTU Graduate Institute of Clinical Pharmacy
Fang-Ju Lin, Associate Professor, NTU Graduate Institute of Clinical Pharmacy


< 25th November >

Updated: Nov. 19, 2021
November 25 (Day 1)
Time Topics Speakers Session Chairs
08:15 - 08:45 Registration
08:45 - 09:00 Opening Remark  
Professor Yen-Hsuan Ni, MD, PhD
Dean, College of Medicine, National Taiwan University
Professor Jaw-Jou Kang, PhD
APN Taiwan Dean, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University
Professor Kyungsoo Park, PhD, MD
Chair, Asian Pharmacometrics Network, Yonsei University, Korea
09:00 - 10:00 Plenary Lecture 1
Concentration Controlled Dosing – TDM is Dead! Long Live TCI!		 Professor Nick Holford
University of Auckland, New Zealand 		Yoke-Lin Lo
Chun-Jung Lin
10:00 - 10:15 Group photo
10:15 - 10:30 Break 1 & e-Poster*
10:30 - 11:00 Pharmacometrics in Taiwan: Academic, Regulatory, Clinical,
and Industry Implications 		Dr. Chen-Hsi Chou
National Cheng Kung University, Taiwan 		Chun-Jung Lin
Uthpali Mannapperuma
11:00 - 11:30 Pharmacometrics in Japan Dr. Takahiko Tanigawa
PPKPD for Drug Development
General Incorporated Association, Japan		 Atsunori Kaibara
Li-Heng Pao
11:30 - 12:00 The Strategy of Sparse Data Sampling in the Pharmacokinetic Study of Levofloxacin Professor Akhmad Kharis Nugroho
Universitas Gadjah Mada, Indonesia
12:00 - 13:00 Lunch & e-Poster*
13:00 - 13:30 Expanded Doses of Dulaglutide: An Example of Model-Informed Drug Development (MIDD) Dr. Lai San Tham
Eli Lilly, Singapore 		Surulivel Rajan Mallayasamy
Yu-Tse Wu
13:30 - 14:00 A Translational Platform Physiologically-based Pharmacokinetic Model for Antibody Disposition in the Brain Dr. Hsueh-Yuan Chang
Boehringer Ingelheim, CT, USA
14:00 - 14:30 Population Longitudinal Analysis of Magnetic Resonance Imaging (MRI) and Time to Climb Four Stairs (4SC) in DMD Patients receiving Domagrozumab Dr. Jiexin Deng
Pfizer, China
14:30 - 15:00 Break 2 & e-Poster*
15:00 - 15:30 Dose Individualization of Vancomycin: from TDM to MIPD Dr. Dinh HoaVu
Vietnaam Ntional DI and ADR Center, Viet Nam 		Tran Manh Hung
Teh-Min Hu

15:30 - 16:30
(15 min per presentation)

 Oral Presentation Population Pharmacokinetics of Ciprofloxacin in Pakistani Patients Suffering from Enteric Fever Saleem Rabia
Lahore Medical and Dental College, Pakistan 		Muhammad Usman
Teh-Min Hu
Using Physiologically based Pharmacokinetic (PBPK) Modeling for the Development of Long Acting Injectable Formulations Chih-Sheng Hsu
Taipei Medical University, Taiwan
Generalizable Model Development for Tacrolimus in Adult Renal Transplant Recipients: Pharmacometric Simulations Approach Dr. Arun Prasath R, PharmD (PhD candidate)
Department of Pharmacy Practice, MCOPS, Manipal, MAHE, India
Model-based Risk Prediction of Rivaroxaban with Amiodarone for Moderate Renal Impaired Elderly Population Dr. Ziteng Wang
National University of Singapore, Singapore
16:30 – 16:45 Closure of Day 1 Yunn-Fang Ho
*Moderator: Fang-Ju Lin, Associate Professor, NTU Graduate Institute of Clinical Pharmacy



< 26th November >

November 26 (Day 2)
Time Topics Speakers Session Chairs
08:15 - 08:45 Registration
09:00 - 10:00 Plenary Lecture 2
Regulatory Science Perspective on Clinical Pharmacology Strategy for Drug Development		 Dr. Shiew-Mei Huang, FDA, USA Jaw-Jou Kang
Rujia Xie
10:00 - 10:15 Group photo
10:15 - 10:30 Break 1 & e-Poster*
10:30 - 11:00 Establishing Quantitative Science Platforms to Support Global Health Product Development Dr. Ping Zhao
Bill & Melinda Gates Foundation, USA 		Jaw-Jou Kang
Rujia Xie
11:00 - 11:30 Pharmacometrics for COVID-Related Drug Developmen Dr. Jenny Yueh Ling Chien,Eli Lilly, USA Lai San Tham
Chin-Chuan Hung
11:30 - 12:00 Dose Optimization of Vancomycin among Surgical Patients in Pakistan: A Population Pharmacokinetic Approach Dr. Muhammad Usman University of Veterinary and Animal Sciences, Lahore, Pakistan
12:00 - 13:00 Lunch & e-Poster*
13:00 - 14:00 Plenary Lecture 3
The Use of Real-World Data in Drug Development		 Professor Kyungsoo Park
Yonsei University, Korea 		Korbtham Sathirakul
Surulivel Rajan Mallayasamy
14:00 - 14:30 Therapeutic Pharmacometric Models and Their Application in Design of Dosage Regimen Dr. Surulivel Rajan Mallayasamy
Manipal Academy of Higher Education, Manipal, India 		Korbtham Sathirakul
Chen-Hsi Chou
14:30 - 15:00 Break 2 & e-Poster*
15:00 - 15:30 Towards Precision Dosing in Oncology: Modeling of 5-Fluorouracil as an Example Dr. Yunn-Fang Ho
National Taiwan University, Taiwan 		Korbtham Sathirakul

15:30 - 16:15
(15 min per presentation)

 Oral
Presentation		 An Optimal Dosage Regimen Design Scheme to Minimize Paclitaxel and Cisplatin Induced Myelosuppression in Non-small Cell Lung Cancer Dr. Kyemyung Park, MD, PhD (Postdoctoral fellow), Korea Akhmad Kharis Nugroho
Chien-Ming Hsieh
Classification Tree Analysis Based on Machine Learning for Predicting Linezolid-Induced Thrombocytopenia Saki Takahashi
School of Pharmacy, Nihon University, Japan
Predictive Performance of Population Pharmacokinetic Models of Amikacin in Neonates Dr. Saikumar Matcha, PharmD (PhD Candidate), Department of Pharmacy Practice, MCOPS, Manipal, MAHE, India
16:15 - 16:45 Population Pharmacokinetics and Dosing Simulations of Oxycodone in Adult Surgical Patients with Obesity Dr. Sook Hui Chaw,Associate Professor,Department of Anaesthesiology, Faculty of Medicine, University of Malaya Yoke-Lin Lo
Bimal Kunwar
16:45 – 17:00 Closing Remark Professor Kyungsoo Park, APN Chair
*e-Poster: online platform, max. 50 posters (poster + presenter's 2-3 min oral introduction)
The 2021 APN Satellite Workshop

<Title of the workshop>
Pharmacometric modelling & simulation with Pumas.jl
< Dates and Time >
November 21 (Sun.) – 24 (Wed.), 2021
11:00 – 15:00 (GMT+8, Taiwan time)


<Target audience >
This workshop is designed for beginners and relatively experienced individuals dealing with clinical pharmacology related data analytics in their day to day work.
Individuals interested in performing Non-compartmental analysis on their clinical data or use basic or advanced non-linear mixed effects models to capture the variability in drug pharmacokinetics or response and the contribution of covariate effects and/or simulate new dosing scenarios or clinical trials will find this workshop interesting.

< Workshop sponsor >
Pumas-AI, Inc.

< Workshop faculty >
Name(s): Dr. Vijay Ivaturi
Affiliations: University of Maryland School of Pharmacy
Bio: Vijay Ivaturi is a clinical pharmacologist and pharmacometrician by training and has worked on multiple drug development and clinical therapeutic programs. His primary research focus is on developing tools and methods to bridge the gap between decision-makers and the scientists, with a special focus on clinical therapeutics in paediatrics. Some of the dosing algorithms he has developed are currently being used in paediatric hospitals around the country. Vijay is passionate about democratizing tools and education for clinical and pharmaceutical research. He is the co-founder and developer of the Pumas software and is creating the next generation tooling for pharmacometrics. He obtained his doctorate in experimental and clinical pharmacology from the University of Minnesota, which he followed with a post-doctoral fellowship in pharmacometrics at Uppsala University in Sweden.

< Workshop overview >
Pharmaceutical Modelling and Simulation (Pumas) is a domain-specific extension of the Julia differential equation solver libraries for performing analyses of pharmacometric models.
We will start by showing users how to implement PK/PD models with complex dosing schedules and incorporating population models.
Then we will turn to the process of estimating population parameters from data.
Next, the capability of Pumas to perform common pre-clinical and clinical data analytics work flows such as Non-compartmental analysis (NCA), In vitro- in vivo correlation (IVIVC), Bio-equivalence (BE) and Clinical Trial Design (CTS) will be introduced.
This workshop will be a mix of demonstration and hands-on work where participants will be able to download the Pumas software and perform the analysis in real-time.
At the end of the workshop, participants will have an overview of the Pumas toolkit and its utility in modern age computing.

< Workshop Learning Objectives >
At the end of the workshop, participants will:
  • 1. Gain an overview of the Pumas modelling ecosystem
  • 2. Learn how to perform Non-compartmental Analysis in Pumas
  • 3. Learn how to simulate using non-linear mixed effects models in Pumas
  • 4. Learn the different estimation methods and perform data analysis using Pumas NLME
  • 5. Learn how to perform post-processing of results for reporting

< Workshop Timetable >

Course 1 [Nov. 21 (Sun.)]:
  • 11:00 – 11:15 Introduction and landscape overview of Pumas
  • 11:15 – 11:45 Demo of Non-Compartmental analysis using Pumas-NCA GUI
  • 11:45 – 12:30 Hands-on with NCA
  • 12:30 – 12:45 Break
  • 12:45 – 13:45 Demo Case study on Population NLME Analysis
  • 13:45 – 15:00 Hands-on Population Pharmacokinetic Analysis

Course 2 [Nov. 22 (Mon.)]:
  • 11:00 – 12:00 Understanding the Pumas Model Syntax
  • 12:00 – 12:30 Dosage Regimens, Subjects, Populations
  • 12:30 – 12:45 Break
  • 12:45 – 13:45 Demo Case study on simulation
  • 13:45 – 15:00 Hands-on Simulations
    •

    Course 3 [Nov. 23 (Wed.)]:
    • 11:00 – 12:00 Understanding data requirements in Pumas
    • 12:00 – 12:30 Fitting Workflow
    • 12:30 – 12:45 Break
    • 12:45 – 13:45 Demo on post-processing options
    • 13:45 – 15:00 Hands-on post-processing

    Course 4 [Nov. 24 (Thur.)]:
    • 11:00 – 12:00 Demo on Multiple response PKPD models
    • 12:00 – 12:30 Demo on Discrete data models
    • 12:30 – 12:45 Break
    • 12:45 – 15:00 Hands-on case study

    < Registration Fee >
    Free . Participants are expected to learn and complete the tasks and assignments for
    registration and progression through the workshop.


    < Maximum Number Participants >
    No limit

    < Requirements >
    Participants are expected to bring their laptops. After registration, participants will be
    sent a link with certain prerequisites to be completed before attending the course.
    The 2022 APN Symposium
    2022 Asian Pharmacometrics Network (APN) Symposium
    9-10th November (Virtual)
    Programme (online)
    Time 2022 November 9 (Day 1, Wednesday) 2022 November 10 (Day 2, Thursday)
    08:15 - 08:45 Registration
    08:45 - 09:00 Opening Remark
    Professor Dr. Park Kyungsoo, APN Chair    		 Dr. Siti Maisharah Sheikh Ghadzi –Malaysia
    Introduction of the Population Approach Group of Malaysia
    [Chairperson: Dr. Shamin Mohd Saffain]
    09:00 - 10:00 Plenary Lecture 1
    Professor Dr. Wei Zhao – Shandong University, China
    Pharmacometrics in pediatric drug development: Something old and something new

    [Chairpersons: Dr. Peter Liu & Assoc. Prof. Dr. Yoke Lin Lo]
    YuWang.Liu@pfizer.com
    yokelinlo@gmail.com     		Plenary Lecture 3
    Professor Dr. Stephen Duffull – University of Otago, New Zealand
    VPs, QSPs, Ensembles and Education: Teaching Clinical Pharmacology in the 21st Century

    [Chairpersons: Professor Park Kyungsoo & Dr. Shamin Mohd Saffain]
    KSPARK@yuhs.ac
    shamin@ukm.edu.my
    10:00 - 10:30 Photo session, Break 1 & e-Poster*
    10:30 - 11:00 Dr. Siti Maisharah Sheikh Ghadzi – Universiti Sains Malaysia, Malaysia Pharmacokinetic/pharmacodynamic modelling using therapeutic drug monitoring data: Experience from cyclosporine

    [Chairpersons: Professor Park Kyungsoo & Dr. Sabariah Noor Harun]
    KSPARK@yuhs.ac
    sabariahnoor@usm.my     		Dr. Emoto Chie – Chugai Pharmaceutical, Japan
    The applications of physiologically-based pharmacokinetic modeling to drug discovery: Current status and future challenges

    [Chairpersons: Dr. Atsunori Kaibara & Dr. Li Ling Yeap]
    kaibara_atsunori@lilly.com
    lilingyeap@gmail.com
    11:00 - 11:30 Professor Park Kyungsoo - Yonsei University College of Medicine, Korea Establishment of Asian Big Health Data Network

    [Chairpersons: Assoc. Prof Dr. Yoke Lin Lo & Dr. Sabariah Noor Harun]
    YokeLinLo@gmail.com
    sabariahnoor@usm.my     		Professor Dr. Dongyang Liu – Peking University Third Hospital China
    Model-informed drug development (MIDD) progression for novel anti-diabetic drugs:
    Our practice and thinking

    [Chairpersons: Dr. Peter Liu & Dr. Li Ling Yeap]
    YuWang.Liu@pfizer.com
    lilingyeap@gmail.com
    11:30 - 12:00 Dr. Vu Dinh Hoa – Hanoi University of Pharmacy, Vietnam
    Dose optimization of meropenem in critically ill patients treated in highly resistant Klebsiella pneumoniae environment

    [Chairpersons: Dr. Tham Lai San & Assoc. Prof. Dr. Sook Hui Chaw]
    tham_lai_san@lilly.com
    chawsookhui@gmail.com    		 Dr. Cheng Cai Tang
    Parexel International Singapore Modeling and simulation for switching between GLP-1 receptor agonists

    [Chairpersons: Dr. Atsunori Kaibara & Dr. Sabariah Noor Harun]
    kaibara_atsunori@lilly.com
    sabariahnoor@usm.my
    12:00 - 12:30 Professor Dr. Surulivelrajan Mallayasamy – Manipal College of Pharmaceutical Sciences, India
    Generalized pharmacometrics model for dose individualisation of imatinib in chronic myeloid leukemia

    [Chairpersons: Dr. Tham Lai San & Associ.Prof. Dr. Sook Hui Chaw]
    tham_lai_san@lilly.com
    chawsookhui@gmail.com     		Dr. Yunn-Fang Ho – National Taiwan University, Taiwan
    Demystifying warfarin dosing puzzles using a pharmacometrics approach

    [Chairpersons: Dr. Tham Lai San & Dr. Sabariah Noor Harun]
    tham_lai_san@lilly.com
    sabariahnoor@usm.my
    12:30 - 13:30 Lunch & e-Poster*
    Chairpersons: Dr. TRAN Manh Hung & Dr. Hadzliana Zainal
    tranmanhhung@uphcm.edu.vn
    hadz@usm.my     		Chairpersons: Assistant Prof. Dr. Muhammad Usman & Dr. Hadzliana Zainal
    usman.ips@uvas.edu.pk
    hadz@usm.my
    13:30 - 13:45 APN-O-2206
    Mr Austin Yue Feng Tan
    Development of pharmacokinetic/pharmacodynamic (PKPD)
    database of dapagliflozin for the treatment of type 2 diabetes mellitus (T2DM)    		 APN-O-2201
    Associate Prof Dr Manupat Lohitnavy
    Physiologically Based Pharmacokinetic Modelling of Ketamine
    13:45 - 14:00 APN-O-2211
    Dr Thi Van Anh Nguyen
    External evaluation of published population pharmacokinetic models of tacrolimus in Vietnamese renal transplant recipients    		 APN-O-2022
    Dr Hai-Ni Wen
    Predicting drug-drug interaction with physiologically based pharmacokinetic/pharmacodynamic modelling and optimal dosing of oral anti-coagulants with dronedarone co-administration
    14:00 - 14:15 APN-O-2216
    Dr Orwa Albitar
    Semi-physiological Pharmacokinetic Model of Clozapine and Norclozapine and the Effect of CYP1A2 and ABCB1 Polymorphism    		 APN-O-2204
    Prof Dr Korbtham Sathirakul
    PBPK Simulation of Andrographolide after Intraarticular Injection by Incorporating protein-binding in Artificial Synovial Fluid and Permeability through Synovial Membrane Parameters using gastroplus® Program via Cloud Computing
    14:15 - 14:30 Question and answer
    14:30 - 15:00 Professor Dr. Akhmad Kharis Nugroho – Universitas Gadjah Mada, Indonesia Handling of the sparse pharmacokinetics data in Monolix and NLMIXR

    [Chairpersons: Dr. Tham Lai San & Dr. Ami Fazlin Syed Mohamed
    tham_lai_san@lilly.com
    ami.syedmohamed@gmail.com]     		Assistant Professor Dr. Muhammad Usman – The University of Veterinary and Animal Sciences, Pakistan.
    Population Pharmacokinetics of linezolid in Pakistani patients

    [Chairpersons: Assistant Prof. Dr. Muhammad Usman & Dr. Siti Maisharah Sheikh Ghadzi
    usman.ips@uvas.edu.pk
    maisharah@usm.my
    15:00 - 15:30 Break 2 & e-Poster*
    15:30 - 16:30 Plenary Lecture 2
    Professor Dr. Mats Karlsson – Uppsala Universitet, Sweden
    Brain disease, composite scores and item response theory models
    (8:30 – 9:30 h Swedish time)

    [Chairpersons: Professor Dr. Park Kyungsoo & Dr. Ami Fazlin Syed Mohamed]
    KSPARK@yuhs.ac
    ami.syedmohamed@gmail.com     		Plenary Lecture 4
    Professor Dr. Joseph Standing - University College London, UK
    Pharmacometrics in 2022: Examples from our recent research
    (7:30 – 8:30 h The UK time)

    [Chairpersons: Dr. Tham Lai San & Dr. Siti Maisharah Sheikh Ghadzi]
    tham_lai_san@lilly.com
    maisharah@usm.my
    16:30 - 17:00 Associate Professor Dr. Johan G. C. van Hasselt – Leiden University, The Netherlands
    Virtual patient stimulation using copula modeling
    (9:30 – 10:00 Dutch time)

    [Chairpersons: Professor Dr. Surulivelrajan Mallayasamy & Dr. Mohd Yusmaidie Aziz]
    msvragavrajan@gmail.com
    mohd.yusmaidie@usm.edu.my     		Professor Dr. Joel Tarning –Mahidol University (Thailand), Oxford University (UK) Primaquine treatment in lactating women is safe for the breastfed infant

    [Chairpersons: Professor Dr. Surulivelrajan Mallayasamy & Dr. Qing Xi Ooi]
    msvragavrajan@gmail.com
    ooi.qingxi@gmail.com
    17:00 - 17:30 Dr. Frank Kloprogge – University College London, UK
    Antimicrobial PK-PD and PKPDDai
    (9:00 – 9:30 h The UK time)

    [Chairpersons: Professor Dr. Surulivelrajan Mallayasamy & Dr. Mohd Yusmaidie Aziz
    msvragavrajan@gmail.com
    mohd.yusmaidie@usm.edu.my     		Associate Professor Dr. Maria Kjellsson - Uppsala Universitet, Sweden
    Multi-state Markov-model of disease progression in Type 2 diabetes
    (10:00 – 10:30 h Swedish time)

    [Chairpersons: Dr. Tham Lai San & Dr. Qing Xi Ooi]
    tham_lai_san@lilly.com
    ooi.qingxi@gmail.com
    17:30 - 17:35 End of Day 1 programme Closing Remarks
    Organising Committee chairperson
    Associate Professor Dr. Lo Yoke Lin
    The 2022 Satellite Workshop
    <Hands on with Monolix>
    The participants will have the chance to work on a hands-on exercise between the two sessions. A presentation of the solution of the hands-on exercise will be done at the beginning of the second day and the solution will also be explained step by step in the slides.
    Monday 7th November, 2:30pm-5:30pm Malaysian Time
    Development of population pharmacokinetic models with MONOLIX
    • • Theoretical recap on the population approach
    • • Data formatting and data visualization
    • • Setup of a Monolix run (data definition, structural model, statistical model)
    • • Estimation tasks and model diagnostic with the plots and statistical tests
    • • Stepwise development of the structural model (using the model libraries)
    • • Stepwise development of the statistical model, including covariate search
    • • Presentation of the hands-on exercise
    Tuesday 8th November, 2:30pm-5:30pm Malaysian Time
    Development of population PKPD models with Monolix and simulation of a new scenarios in Simulx
    • • Presentation of the hands-on solution
    • • Mlxtran language for custom model writing
    • • PKPD model development strategies (sequential, joint)
    • • Export of a Monolix run to Simulx
    • • Definition of the simulation of new scenarios, in particular new dosing regimens
    • • Post-processing of simulation results
    • • Presentation of the hands-on exercise
    The 2023 APN Symposium
    Time Day 1: November 29, 2023 (Wed) Day 2: November 30, 2023 (Thu)
    08:30 – 08:45 Registration
    08:45 – 09:00 Opening Remarks
    Prof. Kyungsoo Park
    – Yonsei University, Korea
    APN President

    Prof. Yasuhiro Tsuji
    – Nihon-University, Japan
    Host of APN Annual Meeting 2023/2024     		[08:55 – 09:00] Day 2 Opening
    Prof. Yasuhiro Tsuji
    – Nihon-University, Japan
    Host of APN Annual Meeting 2023/2024
    09:00 – 10:30 (– 10:30 on Day 1 only) Plenary Session
    ICH M15 MIDD guideline
    Dr. Iwata Daisuke – PMDA, Japan
    Dr. Norisuke Kawai – Pfizer, Japan
    Kenya Nakai – Esai, Japan
    [Chair: Dr. Jenny Chien – Assoc. VP, PK/PD, Eli Lilly, U.S.A.]     		[6, 09:00 – 09:45] Dr. Dongwoo Kang
    – Teva Pharmaceutical, U.S.A
    Bounded Integer Modeling of Abnormal Involuntary Movement Scale (AIMS) Score in Patients with Tardive Dyskinesia
    [Chair: Kyungsoo Park]
    [7, 09:45 – 10:30] Prof. Soyoung Lee
    – Seoul National University and Hospital, Seoul National University Graduate School, Korea
    Bridging from Preclinical to Clinical in Oncology Drug Development
    [Chair: Kyungsoo Park]
    10:30 – 10:45 Break
    10:45 – 11:30 [1] Philippe Auvaro
    – Medical Data Vision Co., Ltd.
    Unlocking Insights from Real-World Data in Pharmacometrics
    [Chair: Yasuhiro Tsuji]     		[8] Prof. Yasuhiro Tsuji
    – Nihon-University, Japan
    Predictive modeling of linezolid-Induced thrombocytopenia using population pharmacokinetics-pharmacodynamics and machine learning
    [Chair: Atsunori Kaibara]
    11:30 – 12:15 [2] Ayako Mori, and Kaoru Suzuki
    – EPS Corporation
    Drug Development Support Applied Pharmacometrics Approach
    [Chair: Atsunori Kaibara]     		[9] Dr. Sung Kweon Cho
    – Ajou University, Korea
    Integration of Pharmacogenomics and Pharmacometrics
    [Chair: Kyungsoo Park]
    12:15 – 13:30 Lunch Break
    13:30 – 13:45 Student Sessions
    [S-1] Yu-Ting Huang
    – National Taiwan University
    Physiologically Based Mechanistic Insight into Differential Risk of Valproate Hepatotoxicity between Children and Adults: A Focus on Ontogeny Impact
    [Chair: Yunn-Fang Ho]     		Student Sessions
    [S-5] Sukyong Yoon
    – Yonsei University, Korea
    Model-informed precision dosing in vancomycin treatment
    [Chair: Kyungsoo Park]
    13:45 – 14:00 [S-2] Dimas Adhi Pradana
    – Public Health and Nursing Universitas Gadjah Mada Yogyakarta, Indonesia
    Population PKPD of Metformin in Type 2 Diabetes Mellitus patients: Analysis of Sparse Sampling Data
    [Chair: Akhmad Kharis Nugroho]     		[S-6] FOONG Keng Wah
    – Universiti Malaya
    PopED for optimal sampling points: A case among perioperative patients
    [Chair: Yoke-Lin Lo]
    14:00 – 14:15 [S-3] Dr. Janice Goh
    – Bioinformatics Institute, A*STAR
    Translational predictions of Phase 2a first in human trials for tuberculosis drugs using preclinical in vivo and in vitro data
    [Chair: Lai San Tham]     		[S-7] Ammara Zamir
    – Bahauddin Zikarya University, Pakistan
    An In-Depth Examination of Physiologically Based Pharmacokinetic Modeling in the Context of Chronic Kidney Disease: A Comprehensive Review of Existing Models
    [Chair: Muhammad Usman]
    14:15 – 14:30 [S-4] Austin Tan
    – National University of Singapore
    Using Phase 1 Glycemic Data in the Evaluation of Two Semi-mechanistic PK/PD Models for Predicting Long-term HbA1c in Type 2 Diabetes
    [Chair: Lai San Tham]     		[S-8] Dr. Sejung Hwang
    – Seoul National University and Hosptial
    Evaluation and prediction of drug transporter-mediated drug-drug interactions of methotrexate using physiologically based pharmacokinetic modeling
    [Chair: Kyungsoo Park]
    14:30 – 14:45 Coffee Break
    14:45 – 15:30 [3] Dr. Shamin Mohd Saffian
    – Universiti Kebangsaan Malaysia
    Population pharmacokinetic model of intravenous immunoglobulin G in patients treated for various immune system disorders
    [Chair: Yoke-Lin Lo]     		[10] Assoc. Prof. VU Dinh Hoa
    – Ha Noi University of Pharmacy, Viet Nam
    Development of MIPD for vancomycin
    [Chair: TRAN Manh Hung]
    15:30 – 16:15 [4] Dr. Guan (Xiaoduo Guan)
    – Pharmacometrics, Pfizer China
    topic on Clinical Trial Simulation
    [Chair: Wei, Hua]     		[11] Dr. Subramanian Ganesasundararajan
    – Pharmacology department of Certara
    Cardiovascular safety assessment: Concentration-QTc assessment in Drug Development
    [Chair: Surulivel rajan Mallayasamy]
    16:15 – 16:30 Coffee Break
    16:30 – 17:15 [5] Sanae Fujita
    – ClinChoice, K.K., Tokyo
    ClinChoice - as an Asia-centric CRO, overview, and experience in Asia
    [Chair: Yasuhiro Tsuji]     		[12] Assistant Prof. Swantje Völler
    – Leiden University, Netherlands
    A framework for evaluating pediatric population PK models
    [Chair: Muhammad Usman]
    17:15 – 17:30 Closing of Day 1 & Introduction of APN2024
    Prof. Yasuhiro Tsuji
    – Nihon-University, Japan
    Host of APN Annual Meeting 2023/2024     		Closing APN2023
    Organizing Committee chairperson
    Dr. Atsunori Kaibara
    – Eli Lilly, Japan
    Japan Representative, APN Board